Engineering strategies for lymph node targeted immune activation

Y Chen, S De Koker, BG De Geest - Accounts of chemical …, 2020 - ACS Publications
nanoparticle delivery to lymph nodes: (1) direct lymph node … surface will enhance B cell
activation by triggering multiple B … PhD in Immunology on the development of synthetic vaccine

Nanotechnology-based approaches to promote lymph node targeted delivery of cancer vaccines

R He, J Zang, Y Zhao, H Dong, Y Li - ACS Biomaterials Science & …, 2022 - ACS Publications
… inhibits and eliminates cancer by activating the immune system. … vaccines to reactivate
antitumor immune response and … or chemical synthesis, achieve the specific targeting with locally …

Engineered nanoparticles for cancer vaccination and immunotherapy

ME Aikins, C Xu, JJ Moon - Accounts of chemical research, 2020 - ACS Publications
… of tumor antigens as immune targets while exploiting … to lymph nodes, generating strong
antitumor T cell immunity. … able to elicit antitumor immunity against disseminated tumors…

Targeting the innate immune system with nanoparticles for cancer immunotherapy

K Li, Z Zhang, Y Mei, M Li, Q Yang, Q Wu… - Journal of Materials …, 2022 - pubs.rsc.org
… microenvironment to enhance antitumor immunity. Such … ) in lymph nodes, the tumor immune
microenvironment and … triggering potent macrophage-related anti-tumor immune responses…

[HTML][HTML] Innate and adaptive immune responses toward nanomedicines

IM de Oliveira Viana, S Roussel, J Defrêne… - … Pharmaceutica Sinica B, 2021 - Elsevier
… Importantly, the lysis of target cells by NK cells promotes … lymph nodes could impact lymphatic
flow 101 . In a parallel study, intradermal injection of non-PEGylated polymer nanoparticles

Nanoparticle-based approaches to target the lymphatic system for antitumor treatment

X Peng, J Wang, F Zhou, Q Liu, Z Zhang - Cellular and Molecular Life …, 2021 - Springer
… system, can provide amplified antitumor immune responses … correlated synthetic ligands are
expected to target lymph nodes … and trigger structural and pathophysiological changes in the …

A pH-/Enzyme-Responsive nanoparticle selectively targets endosomal toll-like receptors to potentiate robust cancer vaccination

H Xia, M Qin, Z Wang, Y Wang, B Chen, F Wan… - Nano Letters, 2022 - ACS Publications
… only in draining lymph nodes after subcutaneous injection, … In order to further explore
long-term antitumor immunity, tumor-free mice … In summary, an endosome-targeted TLR-activating

Lymph node-targeting nanovaccines for cancer immunotherapy

Q Wang, Z Wang, X Sun, Q Jiang, B Sun, Z He… - Journal of Controlled …, 2022 - Elsevier
… on the basis of biomedical nanotechnology has emerged as one of … targeting LNs to enhance
the antitumor immune responses. LNs-targeting nanovaccines are able to trigger immune

[HTML][HTML] Nanoparticles targeting innate immune cells in tumor microenvironment

H Jang, EH Kim, SG Chi, SH Kim, Y Yang - International journal of …, 2021 - mdpi.com
anti-tumor immunity. DCs specialized in local uptake of antigen from dying cancer cells,
migrate to the draining lymph nodes and … and activating adaptive immunity, the innate immune

Lipid nanoparticle-mediated lymph nodetargeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response

J Chen, Z Ye, C Huang, M Qiu… - Proceedings of the …, 2022 - National Acad Sciences
synthetic lipid used in the COVID-19 vaccine Comirnaty. The … antitumor immunity generated
by our mRNA cancer vaccine. … vaccine reduces the population of Treg cells by activating the …