Engineering strategies for lymph node targeted immune activation
Y Chen, S De Koker, BG De Geest - Accounts of chemical …, 2020 - ACS Publications
… nanoparticle delivery to lymph nodes: (1) direct lymph node … surface will enhance B cell
activation by triggering multiple B … PhD in Immunology on the development of synthetic vaccine …
activation by triggering multiple B … PhD in Immunology on the development of synthetic vaccine …
Nanotechnology-based approaches to promote lymph node targeted delivery of cancer vaccines
R He, J Zang, Y Zhao, H Dong, Y Li - ACS Biomaterials Science & …, 2022 - ACS Publications
… inhibits and eliminates cancer by activating the immune system. … vaccines to reactivate
antitumor immune response and … or chemical synthesis, achieve the specific targeting with locally …
antitumor immune response and … or chemical synthesis, achieve the specific targeting with locally …
Engineered nanoparticles for cancer vaccination and immunotherapy
… of tumor antigens as immune targets while exploiting … to lymph nodes, generating strong
antitumor T cell immunity. … able to elicit antitumor immunity against disseminated tumors…
antitumor T cell immunity. … able to elicit antitumor immunity against disseminated tumors…
Targeting the innate immune system with nanoparticles for cancer immunotherapy
K Li, Z Zhang, Y Mei, M Li, Q Yang, Q Wu… - Journal of Materials …, 2022 - pubs.rsc.org
… microenvironment to enhance antitumor immunity. Such … ) in lymph nodes, the tumor immune
microenvironment and … triggering potent macrophage-related anti-tumor immune responses…
microenvironment and … triggering potent macrophage-related anti-tumor immune responses…
[HTML][HTML] Innate and adaptive immune responses toward nanomedicines
IM de Oliveira Viana, S Roussel, J Defrêne… - … Pharmaceutica Sinica B, 2021 - Elsevier
… Importantly, the lysis of target cells by NK cells promotes … lymph nodes could impact lymphatic
flow 101 . In a parallel study, intradermal injection of non-PEGylated polymer nanoparticles …
flow 101 . In a parallel study, intradermal injection of non-PEGylated polymer nanoparticles …
Nanoparticle-based approaches to target the lymphatic system for antitumor treatment
… system, can provide amplified antitumor immune responses … correlated synthetic ligands are
expected to target lymph nodes … and trigger structural and pathophysiological changes in the …
expected to target lymph nodes … and trigger structural and pathophysiological changes in the …
A pH-/Enzyme-Responsive nanoparticle selectively targets endosomal toll-like receptors to potentiate robust cancer vaccination
H Xia, M Qin, Z Wang, Y Wang, B Chen, F Wan… - Nano Letters, 2022 - ACS Publications
… only in draining lymph nodes after subcutaneous injection, … In order to further explore
long-term antitumor immunity, tumor-free mice … In summary, an endosome-targeted TLR-activating …
long-term antitumor immunity, tumor-free mice … In summary, an endosome-targeted TLR-activating …
Lymph node-targeting nanovaccines for cancer immunotherapy
Q Wang, Z Wang, X Sun, Q Jiang, B Sun, Z He… - Journal of Controlled …, 2022 - Elsevier
… on the basis of biomedical nanotechnology has emerged as one of … targeting LNs to enhance
the antitumor immune responses. LNs-targeting nanovaccines are able to trigger immune …
the antitumor immune responses. LNs-targeting nanovaccines are able to trigger immune …
[HTML][HTML] Nanoparticles targeting innate immune cells in tumor microenvironment
… anti-tumor immunity. DCs specialized in local uptake of antigen from dying cancer cells,
migrate to the draining lymph nodes and … and activating adaptive immunity, the innate immune …
migrate to the draining lymph nodes and … and activating adaptive immunity, the innate immune …
Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response
… synthetic lipid used in the COVID-19 vaccine Comirnaty. The … antitumor immunity generated
by our mRNA cancer vaccine. … vaccine reduces the population of Treg cells by activating the …
by our mRNA cancer vaccine. … vaccine reduces the population of Treg cells by activating the …